Identification and biological evaluation of novel benzothiazole derivatives bearing a pyridine-semicarbazone moiety as apoptosis inducers via activation of procaspase-3 to caspase-3-Reference-Cited by-同舟云学术

Identification and biological evaluation of novel benzothiazole derivatives bearing a pyridine-semicarbazone moiety as apoptosis inducers via activation of procaspase-3 to caspase-3

Published:2019 Issue:3 Volume:10 Page:465-477
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Ma Junjie¹²³⁴^ORCID,Ni Xin¹²³⁴,Gao Yali⁵⁶³⁴,Huang Kun¹²³⁴,Liu Jiaan⁷⁸⁹¹⁰,Wang Yu¹²³⁴,Chen Roufen¹²³⁴,Wang Cuifang¹¹¹²¹³⁴

Affiliation:

1. School of Medicine

2. Huaqiao University

3. Quanzhou

4. China

5. Pharmacy Department

6. The Second Affiliated Hospital of Fujian Medical University

7. Department of Chemistry

8. University of Massachusetts-Amherst

9. Amherst

10. USA

11. College of Oceanology and Food Science

12. Quanzhou Normal University

13. Quanzhou 362000

Abstract

A series of benzothiazole derivatives bearing a pyridine-semicarbazone moiety were identified as apoptosis inducers via activation of procaspase-3 to caspase-3.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Fujian Province

Huaqiao University

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C8MD00624E

Reference26 articles.

1. Human Caspases: Activation, Specificity, and Regulation