The anticancer peptide LL-III binds with nanomolar affinity to human telomeric and cMyc G-quadruplexes-Reference-Cited by-同舟云学术

The anticancer peptide LL-III binds with nanomolar affinity to human telomeric and cMyc G-quadruplexes

Published:2023 Issue:41 Volume:59 Page:6179-6182
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Campanile Marco¹,Oliva Rosario¹,Del Vecchio Pompea¹,Winter Roland²^ORCID,Petraccone Luigi¹^ORCID

Affiliation:

1. Department of Chemical Sciences, University of Naples Federico II, Via Cintia 4, 80126, Naples, Italy

2. Physical Chemistry I – Biophysical Chemistry, Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn Street 4a, Dortmund 44227, Germany

Abstract

LL-III preferentially binds G-quadruplexes involved in carcinogenesis and represents a lead peptide for the development of new peptide-based anticancer drugs.

Funder

Ministero dell'Università e della Ricerca

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC00737E

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