Synthesis and biological evaluation of sulfamoyl benzamide derivatives as selective inhibitors for <i>h</i>-NTPDases-Reference-Cited by-同舟云学术

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Synthesis and biological evaluation of sulfamoyl benzamide derivatives as selective inhibitors for h-NTPDases

Published:2023 Issue:30 Volume:13 Page:20909-20915
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zaigham Zahid Hussain¹,Ullah Saif²,Pelletier Julie³,Sévigny Jean³⁴^ORCID,Iqbal Jamshed²^ORCID,Hassan Abbas¹^ORCID

Affiliation:

1. Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan

2. Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan

3. Centre de recherche du CHU de Québec-Université Laval, Québec City, QC, Canada

4. Département de Microbiologie-Infectiologie et d'Immunologie, Faculté de Médecine, Université Laval, Québec City, QC, Canada

Abstract

Sulfamoyl-benzamides were found to be selective inhibitors against h-NTPDases1, -2, -3, and -8 in sub-micromolar concentration, for instance, compound 3i was found to be the most potent inhibitor of h-NTPDase1 (IC50 = 2.88 ± 0.13 μM).

Funder

Higher Education Commission, Pakistan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA03874B

Reference33 articles.

1. Role of Ectonucleotidases in Synapse Formation During Brain Development: Physiological and Pathological Implications

2. Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) and its inhibitors

3. Zebrafish models: Gaining insight into purinergic signaling and neurological disorders

4. Purinergic Receptors in Adipose Tissue As Potential Targets in Metabolic Disorders

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