Transactivation of the human retinoid X receptor by organotins: use of site-directed mutagenesis to identify critical amino acid residues for organotin-induced transactivation-Reference-Cited by-同舟云学术

Transactivation of the human retinoid X receptor by organotins: use of site-directed mutagenesis to identify critical amino acid residues for organotin-induced transactivation

Published:2015 Issue:7 Volume:7 Page:1180-1188
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Hiromori Youhei¹²³⁴⁵,Aoki Akira¹²³,Nishikawa Jun-ichi⁶⁷⁸⁹,Nagase Hisamitsu¹²³,Nakanishi Tsuyoshi¹²³

Affiliation:

1. Laboratory of Hygienic Chemistry and Molecular Toxicology

2. Gifu Pharmaceutical University

3. Gifu, Japan

4. Department of Pharmacy

5. College of Pharmacy

6. Laboratory of Health Sciences

7. School of Pharmacy and Pharmaceutical Sciences

8. Mukogawa Women’s University

9. Nishinomiya, Japan

Abstract

Organotins, such as tributyltin (TBT) and triphenyltin (TPT), may disrupt endocrine activity in mammals arising from their ability to act as ligands for the retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor γ (PPARγ).

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MT/C5MT00086F

Reference22 articles.

1. Critical appraisal of the evidence for tributyltin-mediated endocrine disruption in mollusks

2. Effects of triphenyltin chloride and five other organotin compounds on the development of imposex in the rock shell, Thais clavigera

3. Trialkyltin Compounds Enhance Human CG Secretion and Aromatase Activity in Human Placental Choriocarcinoma Cells

4. Organotin compounds enhance 17β-hydroxysteroid dehydrogenase type I activity in human choriocarcinoma JAr cells: Potential promotion of 17β-estradiol biosynthesis in human placenta

5. Trialkyltin Compounds Bind Retinoid X Receptor to Alter Human Placental Endocrine Functions

Cited by 25 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Preliminary hazard assessment of a new nature-inspired antifouling (NIAF) agent;Science of The Total Environment;2024-07

2. White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming;Pharmaceuticals;2024-06-16

3. Green production and consumption of textiles and apparel: Importance, fabrication, challenges and future prospects;Journal of Open Innovation: Technology, Market, and Complexity;2024-06

4. Structural characterization of 1,3-bis-tert-butyl monocyclic benzene derivatives with agonistic activity towards retinoid X receptor alpha;Toxicology Letters;2023-01

5. Use of GAL4 factor-based yeast assay to quantify the effects of xenobiotics on RXR homodimer and RXR/PPAR heterodimer in scallop Chlamys farreri;Science of The Total Environment;2022-12