Matching sensitivity to abundance: high resolution immuno-mass spectrometry imaging of lanthanide labels and endogenous elements in the murine brain

Author:

Clases David1234ORCID,Gonzalez de Vega Raquel1234ORCID,Funke Sabrina5678,Lockwood Thomas E.1234,Westerhausen Mika T.1234,Taudte R. Verena910118,Adlard Paul A.121314154ORCID,Doble Philip A.1234ORCID

Affiliation:

1. The Atomic Medicine Initiative

2. University of Technology Sydney

3. Sydney

4. Australia

5. Institute of Inorganic and Analytical Chemistry

6. University of Münster

7. Münster

8. Germany

9. Institute for Experimental and Clinical Pharmacology and Toxicology

10. Friedrich-Alexander-University

11. Erlangen

12. The Florey Institute of Neuroscience and Mental Health

13. The Melbourne Dementia Research Centre

14. The University of Melbourne

15. Parkville

Abstract

This work introduces a new method for immuno-mass spectrometry imaging via quadrupole-based laser ablation-inductively coupled plasma-mass spectrometry instruments that is matched to the abundance of elements in biological tissues.

Funder

Deutsche Forschungsgemeinschaft

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Spectroscopy,Analytical Chemistry

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