Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines-Reference-Cited by-同舟云学术

Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines

Published:2015 Issue:1 Volume:6 Page:120-130
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Jardim Guilherme A. M.¹²³⁴⁵,Guimarães Tiago T.⁶⁷⁸⁵,Pinto Maria do Carmo F. R.⁹¹⁰⁸⁵,Cavalcanti Bruno C.¹¹¹²¹³⁵,de Farias Kaio M.¹¹¹²¹³⁵,Pessoa Claudia¹¹¹²¹³⁵¹⁴,Gatto Claudia C.¹⁵¹⁶¹⁷⁵,Nair Divya K.²¹⁸¹⁹²⁰,Namboothiri Irishi N. N.²¹⁸¹⁹²⁰,da Silva Júnior Eufrânio N.¹²³⁴⁵

Affiliation:

1. Institute of Exact Sciences

2. Department of Chemistry

3. Federal University of Minas Gerais

4. Belo Horizonte-MG

5. Brazil

6. Instituto Nacional de Câncer

7. Hospital do Câncer – Unidade I – Seção de Medicina Nuclear

8. Rio de Janeiro

9. Núcleo de Pesquisas de Produtos Naturais

10. UFRJ

11. Departamento de Fisiologia e Farmacologia

12. UFC

13. Fortaleza

14. Fiocruz – Ceará

15. Institute of Chemistry

16. University of Brasilia

17. Brasilia-DF

18. Indian Institute of Technology Bombay

19. Mumbai 400 076

20. India

Abstract

Naphthoquinone-based chalcone hybrids were synthesized and evaluated for their cytotoxic activity against four cancer cell lines and PBMC. Some of the hybrids exhibited promising anticancer activity with IC₅₀ values < 1 μM.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00371C

Reference47 articles.

1. Future of Cancer Incidence in the United States: Burdens Upon an Aging, Changing Nation

2. P. Boyle and B.Levin, World Cancer Report, 2008, IARC Press, Lyon, 2008, p. 510

3. J. Ferlay , I.Soerjomataram, M.Ervik, R.Dikshit, S.Eser, C.Mathers, M.Rebelo, D. M.Parkin, D.Forman and F.Bray, GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet], International Agency for Research on Cancer, Lyon, France, 2013, http://globocan.iarc.fr, accessed 10 April 2014

4. Synthesis and Structure–Activity Relationships of Lapacho Analogues. 1. Suppression of Human Keratinocyte Hyperproliferation by 2-Substituted Naphtho[2,3-b]furan-4,9-diones, Activation by Enzymatic One- and Two-Electron Reduction, and Intracellular Generation of Superoxide

5. Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi

Cited by 45 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery of Novel Naphthoquinone–Chalcone Hybrids as Potent FGFR1 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling;ACS Omega;2023-08-30

2. Novel NQO1 substrates bearing two nitrogen redox centers: Design, synthesis, molecular dynamics simulations, and antitumor evaluation;Bioorganic Chemistry;2023-05

3. Design, Synthesis, Molecular docking ADMET and anti-bacterial activities of some new benzamides and their corresponding quinazolinone derivatives;Egyptian Journal of Chemistry;2022-11-01

4. Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease M^pro and Papain-like Protease PL^pro of SARS-CoV-2;Journal of Chemical Information and Modeling;2022-08-12

5. Hybrid Molecules Containing Naphthoquinone and Quinolinedione Scaffolds as Antineoplastic Agents;Molecules;2022-08-03