Cinnamaldehyde decreases the invasion and u-PA expression of osteosarcoma by down-regulating the FAK signalling pathway

Author:

Chu Shu-Chen1,Hsieh Yih-Shou23,Hsu Li-Sung4,Lin Chin-Yin24,Lai Yi-An4,Chen Pei-Ni45ORCID

Affiliation:

1. Institute and Department of Food Science, Central Taiwan University of Science and Technology, Taichung, Taiwan

2. Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan

3. Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan

4. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan

5. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan

Abstract

Cinnamaldehyde reduced the u-PA activity and invasiveness of the osteosarcoma cells by targeting the FAK pathway and reducing the expression of N-cadherin and fibronectin and suppressed the pulmonary metastasis of osteosarcoma in mice.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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