Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety-Reference-Cited by-同舟云学术

Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety

Published:2020 Issue:23 Volume:20 Page:4357-4372
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Chramiec Alan¹²³⁴^ORCID,Teles Diogo¹²³⁴⁵^ORCID,Yeager Keith¹²³⁴,Marturano-Kruik Alessandro¹²³⁴⁶,Pak Joseph¹²³⁴,Chen Timothy¹²³⁴,Hao Luke¹²³⁴,Wang Miranda¹²³⁴,Lock Roberta¹²³⁴,Tavakol Daniel Naveed¹²³⁴,Lee Marcus Busub¹²³⁴,Kim Jinho¹²³⁴¹,Ronaldson-Bouchard Kacey¹²³⁴,Vunjak-Novakovic Gordana¹²³⁴⁷^ORCID

Affiliation:

1. Department of Biomedical Engineering

2. Columbia University

3. New York

4. USA

5. Life and Health Sciences Research Institute (ICVS)

6. Department of Chemistry, Materials and Chemical Engineering “G Natta”

7. Department of Medicine

Abstract

In a novel, integrated platform, integration of human bone tumor and cardiac tissues improved predictive accuracy of linsitinib efficacy and safety. This platform mimicked clinical trial results, unlike other pre-clinical models.

Funder

National Heart, Lung, and Blood Institute

National Science Foundation

National Cancer Institute

National Institute of Biomedical Imaging and Bioengineering

Center for Scientific Review

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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