Losartan as an ACE inhibitor: a description of the mechanism of action through quantum biochemistry-Reference-Cited by-同舟云学术

Losartan as an ACE inhibitor: a description of the mechanism of action through quantum biochemistry

Published:2022 Issue:44 Volume:12 Page:28395-28404
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Bezerra Eveline M.¹²^ORCID,de Alvarenga Érika C.³^ORCID,dos Santos Ricardo P.⁴,de Sousa Jeanlex S.²^ORCID,Fulco Umberto L.⁵^ORCID,Freire Valder N.²^ORCID,Albuquerque Eudenilson L.⁵^ORCID,da Costa Roner F.¹^ORCID

Affiliation:

1. Programa de Pós-Graduação em Ciência e Engenharia de Materiais (PPgCEM), Universidade Federal Rural do Semi-Árido (UFERSA), CEP 59625-900, Mossoró, RN, Brazil

2. Departamento de Física, Universidade Federal do Ceará (UFC), CEP 60440-900, Fortaleza, CE, Brazil

3. Departamento de Ciências Naturais, Universidade Federal de São João del-Rei (UFSJ), CEP 36307-352, São João del-Rei, MG, Brazil

4. Engenharia da Computação, Universidade Federal do Ceará (UFC), CEP 62010-560, Sobral, CE, Brazil

5. Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande do Norte (UFRN), CEP 59064-741, Natal, RN, Brazil

Abstract

Projection of the interaction energy with ligands lisinopril (LPR) and losartan (LST) for each amino acid of the somatic angiotensin converting enzyme (sACE) mapped onto the molecular surface, according to the scale bar.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Apoio à Pesquisa do Rio Grande do Norte

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Universidade Federal de São João del-Rei

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA04340H

Reference39 articles.

1. WHO , World Health Organization , 2021 , https://www.who.int/news-room/fact-sheets/detail/hypertension

2. T.Nogrady and D. F.Weaver , Medicinal Chemistry: A Molecular and Biochemical Approach , Oxford University Press , USA , 3rd edn, 2005 , p. 672

3. Integration of calcium and RAS signalling

4. The two homologous domains of human angiotensin I-converting enzyme are both catalytically active

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