Novel alkylaminoethyl derivatives of androstane 3-oximes as anticancer candidates: synthesis and evaluation of cytotoxic effects-Reference-Cited by-同舟云学术

Novel alkylaminoethyl derivatives of androstane 3-oximes as anticancer candidates: synthesis and evaluation of cytotoxic effects

Published:2021 Issue:59 Volume:11 Page:37449-37461
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ajduković Jovana J.¹^ORCID,Jakimov Dimitar S.²,Rárová Lucie³,Strnad Miroslav⁴,Dzichenka Yaraslau U.⁵^ORCID,Usanov Sergey⁵,Škorić Dušan Đ.¹^ORCID,Jovanović-Šanta Suzana S.¹^ORCID,Sakač Marija N.¹

Affiliation:

1. Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, 21000 Novi Sad, Serbia

2. Oncology Institute of Vojvodina, Faculty of Medicine, University of Novi Sad, Put Dr Goldmana 4, 21204 Sremska Kamenica, Serbia

3. Department of Experimental Biology, Faculty of Science, Palacký University, Šlechtitelů 27, CZ-78371 Olomouc, Czech Republic

4. Laboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences, Faculty of Science, Palacký University, Šlechtitelů 27, CZ-78371 Olomouc, Czech Republic

5. Institute of Bioorganic Chemistry NAS of Belarus, Kuprevicha Street, 5/2, Minsk, 220141, Belarus

Abstract

Novel steroid O-alkylated 3-oxyimino derivatives were synthesized and evaluated in vitro for their antitumor properties. The obtained data indicate the potential of these functionalities for the development of new candidates for tumor treatment.

Funder

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja

Grantová Agentura České Republiky

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA07613B

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