Regulation of the innate immune system by fragmented heparin-conjugated lipids on lipid bilayered membranes in vitro

Author:

Adler Anna1ORCID,Fritsch Marlene1,Fromell Karin1,Leneweit Gero23ORCID,Ekdahl Kristina N.14,Nilsson Bo1,Teramura Yuji156ORCID

Affiliation:

1. Department of Immunology, Genetics and Pathology (IGP), Uppsala University, Dag Hammarskjölds väg 20, SE-751 85, Uppsala, Sweden

2. ABNOBA GmbH, Pforzheim, Germany

3. Carl Gustav Carus-Institute, Association for the Promotion of Cancer Therapy, Niefern-Öschelbronn, Germany

4. Linnaeus Center of Biomaterials Chemistry, Linnaeus University, SE-391 82 Kalmar, Sweden

5. Cellular and Molecular Biotechnology Research Institute (CMB), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central Fifth, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan

6. Master's/Doctoral Program in Life Science Innovation (T-LSI), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan

Abstract

Surface modification with heparin is a powerful biomaterial coating strategy that protects against innate immunity activation since heparin is a part of the proteoglycan heparan sulfate on cell surfaces in the body.

Funder

Japan Society for the Promotion of Science

Vetenskapsrådet

Ministry of Education, Culture, Sports, Science and Technology

Horizon 2020

Bundesministerium für Bildung und Forschung

VINNOVA

Bpifrance

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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