An extracellular matrix mimicking alginate hydrogel scaffold manipulates an inflammatory microenvironment and improves peripheral nerve regeneration by controlled melatonin release

Author:

Wang Xu123ORCID,Yao Xiangyun123ORCID,Sun Ziyang123,Jin Yi4ORCID,Yan Zhiwen123ORCID,Jiang Huiquan5,Ouyang Yuanming123,Yuan Wei-En4,Wang Chunyang1,Fan Cunyi123ORCID

Affiliation:

1. Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

2. Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration, Shanghai, China

3. Youth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine, Shanghai, China

4. Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China

5. College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China

Abstract

A schematic diagram of scaffold fabrication and implantation in vivo. The scaffold can effectively restore the ECM-like microenvironment and improve the quality of nerve regeneration by controlled melatonin release.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Science and Technology Commission of Shanghai Municipality

Shanghai Shenkang Hospital Development Center

Shanghai Pudong New Area Health Commission

Shanghai University of Medicine and Health Sciences

Shanghai Municipal Health Commission

University of Shanghai for Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3