An extracellular matrix mimicking alginate hydrogel scaffold manipulates an inflammatory microenvironment and improves peripheral nerve regeneration by controlled melatonin release-Reference-Cited by-同舟云学术

An extracellular matrix mimicking alginate hydrogel scaffold manipulates an inflammatory microenvironment and improves peripheral nerve regeneration by controlled melatonin release

Published:2023 Issue:48 Volume:11 Page:11552-11561
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Wang Xu¹²³^ORCID,Yao Xiangyun¹²³^ORCID,Sun Ziyang¹²³,Jin Yi⁴^ORCID,Yan Zhiwen¹²³^ORCID,Jiang Huiquan⁵,Ouyang Yuanming¹²³,Yuan Wei-En⁴,Wang Chunyang¹,Fan Cunyi¹²³^ORCID

Affiliation:

1. Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

2. Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration, Shanghai, China

3. Youth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine, Shanghai, China

4. Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China

5. College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China

Abstract

A schematic diagram of scaffold fabrication and implantation in vivo. The scaffold can effectively restore the ECM-like microenvironment and improve the quality of nerve regeneration by controlled melatonin release.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Science and Technology Commission of Shanghai Municipality

Shanghai Shenkang Hospital Development Center

Shanghai Pudong New Area Health Commission

Shanghai University of Medicine and Health Sciences

Shanghai Municipal Health Commission

University of Shanghai for Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject