Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains-Reference-Cited by-同舟云学术

Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

Published:2015 Issue:7 Volume:6 Page:1381-1386
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Hay Duncan A.¹²³⁴⁵,Rogers Catherine M.⁵²⁶⁷⁴,Fedorov Oleg⁵²⁶⁷⁴,Tallant Cynthia⁵²⁶⁷⁴,Martin Sarah⁵²⁶⁷⁴,Monteiro Octovia P.⁵²⁶⁷⁴,Müller Susanne⁵²⁶⁷⁴,Knapp Stefan⁵²⁶⁷⁴,Schofield Christopher J.¹²³⁴,Brennan Paul E.⁵²⁶⁷⁴

Affiliation:

1. Department of Chemistry

2. University of Oxford

3. Oxford OX1 3TA

4. UK

5. Structural Genomics Consortium

6. Old Road Campus Research Building

7. Oxford

Abstract

We describe potent and selective inhibitors of the BRD7 and BRD9 bromodomains intended for use as chemical probes to elucidate the biological roles of BRD7 and BRD9 in cells.

Funder

Wellcome Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C5MD00152H

Reference31 articles.

1. Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

2. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

3. BRD7, a Novel PBAF-specific SWI/SNF Subunit, Is Required for Target Gene Activation and Repression in Embryonic Stem Cells

4. Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes

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