Stability and toxicity of heteroleptic organometallic Bi(v) complexes towards Leishmania major-Reference-Cited by-同舟云学术

Stability and toxicity of heteroleptic organometallic Bi(v) complexes towards Leishmania major

Published:2014 Issue:34 Volume:43 Page:12904-12916
ISSN:1477-9226
Container-title:Dalton Trans.
language:en
Short-container-title:Dalton Trans.

Author:

Ong Yih Ching¹²³,Blair Victoria L.¹²³,Kedzierski Lukasz⁴³⁵⁶⁷,Andrews Philip C.¹²³

Affiliation:

1. School of Chemistry

2. Monash University

3. Melbourne, Australia

4. Walter and Eliza Institute of Medical Research

5. Department of Medical Biology

6. University of Melbourne

7. Parkville 3010, Australia

Abstract

A series of organometallic bismuth(v) dicarboxylates, [BiPh₃(O₂CR′)₂], were synthesised and evaluated for their anti-leishmanial activity. The complexes are effective against parasite promastigotes (0.6–2.5 μM), but prone to slow reductive decomposition.

Funder

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/DT/C4DT00957F

Reference29 articles.

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2. Leishmaniasis: Current Treatment and Prospects for New Drugs and Vaccines

3. Use of Antimony in the Treatment of Leishmaniasis: Current Status and Future Directions