In this study, the procedure for analyzing cocainic drugs and metabolites (anhydroecgnonine, anhydroecgnonine methyl ester, benzoylecgonine, cocaine, cocaethylene, ecgnonine ethyl ester, and ecgnonine methyl ester) in whole blood samples obtained from drugs and driving cases using a mixed mode solid phase extraction (SPE) C8/SCX cartridge (Clean Screen DAU206), is described.