The role of breast cancer resistance protein (Bcrp/Abcg2) in triptolide-induced testis toxicity-Reference-Cited by-同舟云学术

The role of breast cancer resistance protein (Bcrp/Abcg2) in triptolide-induced testis toxicity

Published:2015 Issue:5 Volume:4 Page:1260-1268
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

Li Chunzhu¹²³⁴,Xing Guozhen⁵⁶⁷⁸⁴,Maeda Kazuya⁹¹⁰¹¹¹²,Wu Chunyong¹³¹⁴³⁴,Gong Likun⁵⁶⁷⁸⁴,Sugiyama Yuichi⁹¹⁰¹¹¹²,Qi Xinming⁵⁶⁷⁸⁴^ORCID,Ren Jin⁵⁶⁷⁸⁴,Wang Guangji¹²³⁴

Affiliation:

1. State Key Laboratory of Natural Medicines

2. Key Lab of Drug Metabolism and Pharmacokinetics

3. China Pharmaceutical University

4. China

5. Center for Drug Safety Evaluation and Research

6. State Key Laboratory of New Drug Research

7. Shanghai Institute of Materia Medica

8. Chinese Academy of Sciences

9. Graduate School of Pharmaceutical Sciences

10. the University of Tokyo

11. Tokyo

12. Japan

13. Department of Pharmaceutical Analysis

14. School of Pharmacy

Abstract

Triptolide possesses unique immunosuppressive and anti-tumor activities. However, its clinical use is limited by the cumulative toxicity in the testis and the mechanisms are poorly understood.

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/TX/C5TX00058K

Reference54 articles.

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3. Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii