18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2-Reference-Cited by-同舟云学术

18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2

Published:2021 Issue:18 Volume:12 Page:8399-8410
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Chen Boda¹²³,Zhu Dingchao¹²³,Xie Chenglong¹²³,Shi Yifeng¹²³,Ni Libin¹²³,Zhang Huawei¹²³,Li Sunlong¹²³,Lu Jiajie¹²³,Xiao Jian¹²³,Xia Weiyi¹²³,Huang Chongan¹²³,Wang Xiangyang¹²³^ORCID

Affiliation:

1. Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China

2. The Second School of Medicine, Wenzhou Medical University, Wenzhou, China

3. Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China

Abstract

18β-Glycyrrhetinic acid treatment attenuated inflammatory response and ECM degradation in chondrocytes via suppressing NF-κB activity by the Nrf2/HO-1 pathway.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Medical Science and Technology Project of Zhejiang Province

Wenzhou Municipal Science and Technology Bureau

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D1FO01379C

Reference41 articles.