Small molecule antagonists of cell-surface heparan sulfate and heparin–protein interactions-Reference-Cited by-同舟云学术

Small molecule antagonists of cell-surface heparan sulfate and heparin–protein interactions

Published:2015 Issue:10 Volume:6 Page:5984-5993
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Weiss Ryan J.¹²³⁴,Gordts Philip L. S. M.⁵²³⁴,Le Dzung⁶²³⁴⁷,Xu Ding⁸⁹¹⁰⁴,Esko Jeffrey D.⁵²³⁴⁷,Tor Yitzhak¹²³⁴⁷

Affiliation:

1. Department of Chemistry and Biochemistry

2. University of California

3. La Jolla

4. USA

5. Cellular and Molecular Medicine

6. Department of Medicine

7. Glycobiology Research and Training Center

8. Department of Oral Biology

9. University at Buffalo

10. Buffalo

Abstract

A series of rationally designed surfen analogs were synthesized and utilized as antagonists of glycosaminoglycan–protein interactions, including the neutralization of the anticoagulant activity of fondaparinux, a synthetic pentasaccharide analog of heparin.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/SC/C5SC01208B

Reference54 articles.

1. Heparan sulphate proteoglycans: the sweet side of development

2. Heparan sulphate proteoglycans fine-tune mammalian physiology

3. The Molecular Diversity of Glycosaminoglycans Shapes Animal Development