Asymmetric hydrogenation of TIPS-protected oximes with chiral boranes-Reference-Cited by-同舟云学术

Asymmetric hydrogenation of TIPS-protected oximes with chiral boranes

Published:2022 Issue:18 Volume:20 Page:3708-3711
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yu Kuai¹²,Feng Xiangqing¹³^ORCID,Du Haifeng¹³^ORCID

Affiliation:

1. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

2. College of Chemistry and Material Sciences, Hebei Normal University, Shijiazhuang, Hebei 050024, P. R. China

3. University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

A chiral borane-catalyzed metal-free asymmetric hydrogenation of TIPS-protected oximes has been successfully realized to furnish the desired hydroxyamine derivatives without the N–O bond cleavage in high yields with moderate ees.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00602B

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3. Total Synthesis of (±)‐Phyllantidine: Development and Mechanistic Evaluation of a Ring Expansion for Installation of Embedded Nitrogen‐Oxygen Bonds