Photoinduced inhibition of DNA repair enzymes and the possible mechanism of photochemical transformations of the ruthenium nitrosyl complex [RuNO(β-Pic)2(NO2)2OH]-Reference-Cited by-同舟云学术

Photoinduced inhibition of DNA repair enzymes and the possible mechanism of photochemical transformations of the ruthenium nitrosyl complex [RuNO(β-Pic)2(NO2)2OH]

Published:2019 Issue:12 Volume:11 Page:1999-2009
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Mikhailov Artem A.¹²³⁴²,Khantakova Darya V.¹²³⁵²^ORCID,Nichiporenko Vladislav A.¹²³⁶²,Glebov Evgeni M.¹²³⁶²^ORCID,Grivin Vjacheslav P.¹²³⁶²,Plyusnin Victor F.¹²³⁶²,Yanshole Vadim V.¹²³⁷²^ORCID,Petrova Daria V.¹²³⁶²,Kostin Gennadiy A.¹²³⁴²^ORCID,Grin Inga R.¹²³⁵²

Affiliation:

1. Novosibirsk State University

2. Novosibirsk 630090

3. Russia

4. Nikolaev Institute of Inorganic Chemistry SB RAS

5. SB RAS Institute of Chemical Biology and Fundamental Medicine

6. Voevodsky Institute of Chemical Kinetics and Combustion SB RAS

7. International Tomography Center SB RAS

Abstract

Inhibition of DNA repair enzymes by the ruthenium nitrosyl complex occurs only after light irradiation and is determined by the interactions between the enzyme and active photolysis products.

Funder

Russian Foundation for Basic Research

Siberian Branch, Russian Academy of Sciences

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MT/C9MT00153K

Reference63 articles.

1. Ruthenium-based chemotherapeutics: are they ready for prime time?

2. Ruthenium metallopharmaceuticals