A model of modified meta-iodobenzylguanidine conjugated gold nanoparticles for neuroblastoma treatment

Author:

Saimuang Kween12345,Suttisintong Khomson675,Kaewchangwat Narongpol675,Thanayupong Eknarin675,Wongngam Yodsathorn675ORCID,Charoenphun Putthiporn8910311ORCID,Wanotayan Rujira122345,Elaissari Abdelhamid1314151617,Hongeng Suradej18910311,Polpanich Duangporn675ORCID,Jangpatarapongsa Kulachart12345ORCID

Affiliation:

1. Center for Research and Innovation

2. Faculty of Medical Technology

3. Mahidol University

4. Bangkok 10700

5. Thailand

6. National Nanotechnology Center (NANOTEC)

7. National Science and Technology Development Agency (NSTDA)

8. Department of Diagnostic and Therapeutic Radiology

9. Faculty of Medicine

10. Ramathibodi Hospital

11. Bangkok 10400

12. Department of Radiological Technology

13. Univ. Lyon

14. University Claude Bernard Lyon-1

15. CNRS

16. ISA-UMR 5280

17. 69622 Villeurbanne

18. Department of Pediatrics

Abstract

127I-modified mIBG was successfully synthesized and grafted covalently to the surface of carboxylated PEG-GNPs. The particles were not toxic to the normal fibroblast cells while specifically internalized into neuroblastoma cells line via NET.

Funder

Royal Golden Jubilee (RGJ) Ph.D. Programme

Mahidol University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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