Construction of a high fidelity epidermis-on-a-chip for scalable in vitro irritation evaluation-Reference-Cited by-同舟云学术

Construction of a high fidelity epidermis-on-a-chip for scalable in vitro irritation evaluation

Published:2021 Issue:19 Volume:21 Page:3804-3818
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Zhang Jing¹²,Chen Zaozao¹²,Zhang Yaoyao²,Wang Xingchi²,Ouyang Jun²,Zhu Jianfeng²,Yan Yuchuan²,Sun Xiaowei²,Wang Fei²,Li Xiaoran²,Ye Huan²,Sun Shiqi²,Yu Qingdong²,Sun Jiawei²,Ge Jianjun²,Li Qiwei¹,Han Qianqian³,Pu Yuepu⁴,Gu Zhongze¹²^ORCID

Affiliation:

1. State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China

2. Institute of Medical Devices (Suzhou), Southeast University, Suzhou 215163, China

3. National Institutes for Food and Drug Control, Beijing 102629, China

4. Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210096, China

Abstract

We constructed an organotypic epidermis-on-a-chip with integrated barrier function that does not use PDMS material and integrates TEER detection. It could be an alternative in irritation testing according to the OECD 439 method.

Funder

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/LC/D1LC00099C

Reference56 articles.

1. How to improve R&D productivity: the pharmaceutical industry's grand challenge

2. Clinical development success rates for investigational drugs

3. Organ-On-A-Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies