A dynamic microscale mid-throughput fibrosis model to investigate the effects of different ratios of cardiomyocytes and fibroblasts-Reference-Cited by-同舟云学术

A dynamic microscale mid-throughput fibrosis model to investigate the effects of different ratios of cardiomyocytes and fibroblasts

Published:2021 Issue:21 Volume:21 Page:4177-4195
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Mainardi Andrea¹²³^ORCID,Carminati Francesca¹²,Ugolini Giovanni Stefano¹,Occhetta Paola²⁴^ORCID,Isu Giuseppe²,Robles Diaz Diana¹,Reid Gregory¹³^ORCID,Visone Roberta²^ORCID,Rasponi Marco²^ORCID,Marsano Anna¹^ORCID

Affiliation:

1. Departments of Biomedicine and Surgery, University Basel and University Hospital Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland

2. Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy

3. Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland

4. BiomimX S.r.l., Via Giovanni Durando 38/A, 20158 Milano, Italy

Abstract

High percentages of cardiomyocytes mitigate the onset of fibrotic traits induced by fibroblasts in a mid-throughput, mechanically active microdevice.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/LC/D1LC00092F

Reference48 articles.

1. Modeling the Human Scarred Heart In Vitro: Toward New Tissue Engineered Models

2. Cardiac Fibrosis

3. Myofibroblasts and mechano-regulation of connective tissue remodelling

4. Microengineered in vitro model of cardiac fibrosis through modulating myofibroblast mechanotransduction

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