Comb-shaped polymer grafted with REDV peptide, PEG and PEI as targeting gene carrier for selective transfection of human endothelial cells

Abstract

Several REDV peptide molecules are covalently linked onto an amphiphilic block copolymer to obtain REDV-modified polycationic polymer as a gene carrier with targeting function. The targeting gene complexes show high cell recognition and binding affinity to human endothelial cells.