The metalation of hen egg white lysozyme impacts protein stability as shown by ion mobility mass spectrometry, differential scanning calorimetry, and X-ray crystallography-Reference-Cited by-同舟云学术

The metalation of hen egg white lysozyme impacts protein stability as shown by ion mobility mass spectrometry, differential scanning calorimetry, and X-ray crystallography

Published:2017 Issue:30 Volume:53 Page:4246-4249
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Sullivan Matthew P.¹²³⁴⁵^ORCID,Groessl Michael⁶⁷⁸,Meier Samuel M.⁹¹⁰¹¹¹²^ORCID,Kingston Richard L.⁵²³⁴,Goldstone David C.⁵²³⁴,Hartinger Christian G.¹²³⁴^ORCID

Affiliation:

1. School of Chemical Sciences

2. University of Auckland

3. Auckland

4. New Zealand

5. School of Biological Sciences

6. TOFWERK

7. Thun

8. Switzerland

9. Institute of Analytical Chemistry

10. University of Vienna

11. Vienna

12. Austria

Abstract

Metalation of lysozyme with anticancer organometallics results in protein destabilisation, probably relevant in metallodrug mode of action.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C6CC10150J

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5. Systematic Design of a Targeted Organometallic Antitumour Drug in Pre-clinical Development

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