Unfolding knots by proteasome-like systems: simulations of the behaviour of folded and neurotoxic proteins
Author:
Affiliation:
1. Institute of Physics
2. Polish Academy of Sciences
3. PL-02668 Warsaw
4. Poland
5. Instituto Cajal
6. Consejo Superior de Investigaciones Científicas
7. (CSIC)
8. 28002 Madrid
9. Spain
Abstract
Knots in proteins have been proposed to resist proteasomal degradation, thought in turn to be related to neurodegenerative diseases such as Huntington.
Funder
Consejo Superior de Investigaciones Científicas
Publisher
Royal Society of Chemistry (RSC)
Subject
Molecular Biology,Biotechnology
Link
http://pubs.rsc.org/en/content/articlepdf/2016/MB/C6MB00214E
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