Glucose transport via the pseudomonad porin OprB: implications for the design of Trojan Horse anti-infectives-Reference-Cited by-同舟云学术

Glucose transport via the pseudomonad porin OprB: implications for the design of Trojan Horse anti-infectives

Published:2019 Issue:16 Volume:21 Page:8457-8463
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Coines Joan¹²³⁴,Acosta-Gutierrez Silvia⁵⁶⁷⁸⁹^ORCID,Bodrenko Igor⁵⁶⁷⁸⁹,Rovira Carme¹²³⁴¹⁰^ORCID,Ceccarelli Matteo⁵⁶⁷⁸⁹^ORCID

Affiliation:

1. Departament de Química Inorgànica i Orgànica and Institut de Química Teòrica i Computacional (IQTCUB)

2. Universitat de Barcelona

3. 08028 Barcelona

4. Spain

5. Department of Physics

6. University of Cagliari

7. Cittadella Universitaria

8. 09042 Monserrato

9. Italy

10. Institució Catalana de Recerca i Estudis Avançats (ICREA)

Abstract

Knowing the structural and dynamical features of specific porins from poor-permeable Gram-negative bacteria helps to design anti-infectives with optimal permeation. Molecular dynamics simulations can characterize and quantify the transport of substrates through these specific porins.

Funder

Ministerio de Economía y Competitividad

Ministero dell’Istruzione, dell’Università e della Ricerca

Agència de Gestió d’Ajuts Universitaris i de Recerca

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CP/C9CP00778D

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