Speciation of copper in human serum using conjoint liquid chromatography on short-bed monolithic disks with UV and post column ID-ICP-MS detection

Author:

Marković Katarina12ORCID,Cemazar Maja34,Sersa Gregor35,Milačič Radmila12ORCID,Ščančar Janez12ORCID

Affiliation:

1. Department of Environmental Sciences, Jožef Stefan Institute, Ljubljana, Slovenia

2. Jožef Stefan International Postgraduate School, Ljubljana, Slovenia

3. Institute of Oncology Ljubljana, Department of Experimental Oncology, Zaloška cesta 2, 1000 Ljubljana, Slovenia

4. Faculty of Health Sciences, University of Primorska, Polje 42, 6310 Izola, Slovenia

5. Faculty of Health Sciences, University of Ljubljana, Zdravstvena pot 5, 1000 Ljubljana, Slovenia

Abstract

A new method based on conjoint liquid chromatography with post-column ID-ICP-MS detection was developed for the speciation of Cu in human serum. Cu ceruloplasmin (Cu-Cp) is suggested as a potential biomarker in cancer diagnosis.

Funder

Javna Agencija za Raziskovalno Dejavnost RS

Publisher

Royal Society of Chemistry (RSC)

Subject

Spectroscopy,Analytical Chemistry

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