Catalyst-free C(sp3)–H functionalization of methyl azaarenes with heteroaromatic trifluoromethyl ketone hydrates: “all-water” synthesis of α-trifluoromethyl tertiary alcohols

Author:

Wang Wei1,Qin Zhaoliang1,Zhang Xinhui1,Zhao Wanxiang1ORCID,Yang Wen1ORCID

Affiliation:

1. Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, P. R. China

Abstract

An efficient catalyst-free C(sp3)–H functionalization of methyl azaarenes with heteroaromatic trifluoromethyl ketone hydrates in neat water for the synthesis of α-trifluoromethyl tertiary alcohols has been developed.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference51 articles.

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