Metal-free, direct conversion of α-amino acids into α-keto γ-amino esters for the synthesis of α,γ-peptides
Author:
Affiliation:
1. Instituto de Productos Naturales y Agrobiología del CSIC
2. 38206-La Laguna
3. Spain
4. Instituto de Investigaciones Químicas (CSIC-USe)
5. Isla de la Cartuja
6. 41092-Sevilla
Abstract
An efficient, metal-free synthesis of unusual α-keto γ-amino esters from α-amino acids is achieved by a radical scission–oxidation–addition of silyloxy acrylates procedure, where no purification of the reaction intermediates is needed. The process allows the synthesis of α,γ-peptides.
Funder
Ministerio de Economía y Competitividad
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB02033C
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