Design of electron-donating group substituted 2-PAM analogs as antidotes for organophosphate insecticide poisoning

Author:

Kongkaew Nalinee1ORCID,Hengphasatporn Kowit2,Injongkol Yuwanda1,Mee-udorn Pitchayathida3,Shi Liyi45,Mahalapbutr Panupong6,Maitarad Phornphimon45ORCID,Harada Ryuhei2ORCID,Shigeta Yasuteru2ORCID,Rungrotmongkol Thanyada17ORCID,Vangnai Alisa S.7

Affiliation:

1. Program in Bioinformatics and Computational Biology, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand

2. Center for Computational Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan

3. National Center for Genetic Engineering and Biotechnology, 113 Thailand Science Park, Pathumthani 12120, Thailand

4. Research Center of Nano Science and Technology, Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, China

5. Department of Chemistry, College of Sciences, State Key Laboratory of Advanced Special Steel, Research Center of Nano Science and Technology, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China

6. Department of Biochemistry, Center for Translational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand

7. Center of Excellence in Biocatalyst and Sustainable Biotechnology, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand

Abstract

Design of novel 2-pralidoxime analogs by incorporating electron-donating groups onto its pyridinium core to enhance blood–brain barrier permeability and binding susceptibility toward acetylcholinesterase with paraoxon bound.

Funder

Chulalongkorn University

National Research Council of Thailand

Ministry of Education, Culture, Sports, Science and Technology

Mishima Kaiun Memorial Foundation

Sumitomo Foundation

University of Tsukuba

Japan Science and Technology Agency

Thailand Science Research and Innovation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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