A high-throughput, open-space and reusable microfluidic chip for combinational drug screening on tumor spheroids

Author:

Li Lijun12,Chen Yan2,Wang Huirong2,An Geng3,Wu Hongkai14ORCID,Huang Wei2ORCID

Affiliation:

1. Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, 999077, Hong Kong, China

2. Department of Biology, Southern University of Science and Technology, Shenzhen, 518055, Guangdong, China

3. Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, Guangdong, China

4. The Hong Kong University of Science and Technology Shenzhen Research Institute, Shenzhen, 518057, Guangdong, China

Abstract

Screening drug combinations using a high-throughput and open-space DOE microfluidic chip can play a vital role in the development of disease treatment and personalized medicine.

Funder

Shenzhen Fundamental Research Program

National Key Research and Development Program of China

National Natural Science Foundation of China

Science, Technology and Innovation Commission of Shenzhen Municipality

Shenzhen Peacock Plan

Science and Technology Planning Project of Guangdong Province

Ministry of Science and Technology of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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