Introductory Lecture: Mechanochemistry, a versatile synthesis strategy for new materials

Author:

Jones William123,Eddleston Mark D.123

Affiliation:

1. Department of Chemistry

2. University of Cambridge

3. Cambridge, UK

Abstract

Mechanochemistry deals with reactions induced by the input of mechanical energy – for example by impacts within a vibratory ball mill. The technique has a long history with significant contributions from Ostwald, Carey Lea and, notably, Faraday. Mechanochemistry has subsequently seen application in a variety of areas of materials science including mechanical alloying in metallurgy, the synthesis of complex organic molecules and, more recently, the discovery and development of new solid forms of active pharmaceutical ingredients. This paper overviews the broad areas of application of mechanochemistry, some key features which make it a particularly attractive approach to materials synthesis and some mechanistic aspects highlighted within the literature. A significant part, however, will focus on recent applications in the area of pharmaceuticals and its important role in exploring the rich variety of solid forms available for small, drug-like, molecules.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry

Reference161 articles.

1. The mechanochemical reduction of AgCl with metals

2. Mechanochemistry and mechanical activation of solids

3. P. Baláž , Mechanochemistry in Nanoscience and Minerals Engineering , Springer-Verlag , Berlin, Germany , 2008

4. The historical development of mechanochemistry

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