Nucleic acid-based supramolecular structures: vesicular spherical nucleic acids from a non-phospholipid nucleolipid

Author:

Dimitrov Erik1,Toncheva-Moncheva Natalia1ORCID,Bakardzhiev Pavel1,Forys Aleksander2ORCID,Doumanov Jordan3,Mladenova Kirilka3,Petrova Svetla3,Trzebicka Barbara2,Rangelov Stanislav1ORCID

Affiliation:

1. Institute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev St. 103A, 1113 Sofia, Bulgaria

2. Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, Zabrze, Poland

3. Department of Biochemistry, Faculty of Biology, Sofia University St. Kliment Ohridski, Dragan Tsankov Blvd. 8, 1164 Sofia, Bulgaria

Abstract

An original hybrid biomacromolecule, consisting of a lipid-mimetic residue and a 21-base long nucleic acid strand, spontaneously self-associates and co-associates with other lipids into nucleic acid-grafted vesicular structures.

Funder

Bulgarian National Science Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

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