Importance of protein flexibility in ranking ERK2 Type I1/2inhibitor affinities: a computational study-Reference-Cited by-同舟云学术

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Importance of protein flexibility in ranking ERK2 Type I1/2inhibitor affinities: a computational study

Published:2019 Issue:22 Volume:9 Page:12441-12454
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Niu Yuzhen¹²³⁴⁵^ORCID,Yao Xiaojun⁶⁷⁸⁹⁵,Ji Hongfang¹²³⁴⁵

Affiliation:

1. Shandong Provincial Research Center for Bioinformatic Engineering and Technique

2. College of Life Sciences

3. Shandong University of Technology

4. Zibo 255049

5. China

6. State Key Laboratory of Applied Organic Chemistry

7. Department of Chemistry

8. Lanzhou University

9. Lanzhou 730000

Abstract

Extracellular-regulated kinase (ERK2) has been regarded as an essential target for various cancers, especially melanoma.

Funder

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA01657K

Reference52 articles.

1. Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition

2. Dual roles of the MAPK/ERK1/2 cell signaling pathway after stroke

3. Increase of the resistance of human cervical carcinoma cells to cisplatin by inhibition of the MEK to ERK signaling pathway partly via enhancement of anticancer drug-induced NFκB activation

4. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

5. Hyperactive Ras in developmental disorders and cancer

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1. Current developments in extracellular-regulated protein kinase (ERK1/2) inhibitors;Drug Discovery Today;2022-05

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4. Combining Molecular Dynamics and Docking Simulations to Develop Targeted Protocols for Performing Optimized Virtual Screening Campaigns on the hTRPM8 Channel;International Journal of Molecular Sciences;2020-03-25

5. Design, synthesis and biological evaluation of novel amide-linked 18β-glycyrrhetinic acid derivatives as novel ALK inhibitors;RSC Advances;2020

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