DNA binding, DNA cleavage, cellular uptake, cytotoxicity, and apoptosis-inducing ability of a binuclear Schiff base copper(<scp>ii</scp>) complex-Reference-Cited by-同舟云学术

DNA binding, DNA cleavage, cellular uptake, cytotoxicity, and apoptosis-inducing ability of a binuclear Schiff base copper(ii) complex

Published:2022 Issue:31 Volume:46 Page:15219-15226
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Zhao Dandan¹,Wu Yixuan¹,Huang Wenxin¹,Gong Silin¹,Chen Zhanfen¹²^ORCID

Affiliation:

1. Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, School of Optoelectronic Material and Technologies, Jianghan University, Wuhan, 430056, P. R. China

2. Wuhan Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, P. R. China

Abstract

A binuclear Schiff base copper(ii) complex could bind to DNA, efficiently cleave DNA, effectively enter the cancer cells, even the nucleus, induce cellular apoptosis, and exhibit potent cytotoxicity against cancer cell lines.

Funder

Jianghan University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ03077B

Reference42 articles.

1. The resurgence of platinum-based cancer chemotherapy

2. Non-Platinum Chemotherapeutic Metallopharmaceuticals

3. Targeting copper in cancer therapy: ‘Copper That Cancer’

4. Advances in Copper Complexes as Anticancer Agents

5. Mechanisms for copper acquisition, distribution and regulation

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review;Journal of Cancer Research and Clinical Oncology;2024-04-25

2. Syntheses, Structural Characterization, and Cytotoxicity Assessment of Novel Mn(II) and Zn(II) Complexes of Aroyl-Hydrazone Schiff Base Ligand;ACS Omega;2023-01-11