Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks-Reference-Cited by-同舟云学术

Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks

Published:2016 Issue:1 Volume:141 Page:90-95
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Van Nuffel S.¹²³⁴⁵,Parmenter C.⁶⁴⁷,Scurr D. J.¹²³⁴⁵,Russell N. A.⁸⁹⁴⁵⁷,Zelzer M.¹²³⁴⁵

Affiliation:

1. Laboratory of Biophysics and Surface Analysis

2. School of Pharmacy

3. Boots Science Building

4. University of Nottingham

5. Nottingham NG72RD

6. Nottingham Nanotechnology and Nanoscience Centre

7. UK

8. Neurophotonics Lab

9. Faculty of Engineering

Abstract

Here, we demonstrate that by using a training set approach principal components analysis (PCA) can be performed on large 3D ToF-SIMS images of neuronal cell cultures.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/AN/C5AN01743B

Reference20 articles.

1. Static secondary ion mass spectrometry (S-SIMS) Part 2: material science applications

2. TOF-SIMS 3D Imaging of Native and Non-Native Species within HeLa Cells

3. Single-Cell Analysis: Visualizing Pharmaceutical and Metabolite Uptake in Cells with Label-Free 3D Mass Spectrometry Imaging

4. SIMS of organics—Advances in 2D and 3D imaging and future outlook

Cited by 25 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Spatial distribution of active compounds in stratum corneum—partitioning between corneocytes and lipid matrix;Scientific Reports;2024-08-12

2. Identification of Lithium Compounds on Surfaces of Lithium Metal Anode with Machine-Learning-Assisted Analysis of ToF-SIMS Spectra;ACS Applied Materials & Interfaces;2023-10-18

3. Elucidating the molecular landscape of the stratum corneum;Proceedings of the National Academy of Sciences;2022-03-17

4. Applications of multivariate analysis and unsupervised machine learning to ToF-SIMS images of organic, bioorganic, and biological systems;Biointerphases;2022-03

5. Secondary Ion Mass Spectrometry Imaging Reveals Changes in the Lipid Structure of the Plasma Membranes of Hippocampal Neurons following Drugs Affecting Neuronal Activity;ACS Chemical Neuroscience;2021-04-26