Synthesis, characterisation and potent cytotoxicity of unconventional platinum(iv) complexes with modified lipophilicity-Reference-Cited by-同舟云学术

Synthesis, characterisation and potent cytotoxicity of unconventional platinum(iv) complexes with modified lipophilicity

Published:2019 Issue:46 Volume:48 Page:17217-17227
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Deo Krishant M.¹²³⁴^ORCID,Sakoff Jennette⁵⁶⁴^ORCID,Gilbert Jayne⁵⁶⁴,Zhang Yingjie⁷⁴^ORCID,Aldrich Wright Janice R.¹²³⁴^ORCID

Affiliation:

1. Nanoscale Organisation and Dynamics Group

2. Western Sydney University

3. Campbelltown

4. Australia

5. Calvary Mater Newcastle

6. Waratah

7. Australian Nuclear Science and Technology Organisation

Abstract

Platinum(iv) complexes with facile modulation of lipophilicity exhibited nanomolar activity against tested lines. The most potent complexes exhibited 850-fold greater activity than cisplatin against HT29 colon carcinoma with GI₅₀ values of 13 nM.

Funder

University of Western Sydney

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/DT/C9DT03339D

Reference43 articles.

1. Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode

2. Targeting and delivery of platinum-based anticancer drugs

3. Design, synthesis and biological evaluation of estradiol-PEG-linked platinum(II) hybrid molecules: Comparative molecular modeling study of three distinct families of hybrids