Synthesis, characterisation and potent cytotoxicity of unconventional platinum(iv) complexes with modified lipophilicity
Author:
Affiliation:
1. Nanoscale Organisation and Dynamics Group
2. Western Sydney University
3. Campbelltown
4. Australia
5. Calvary Mater Newcastle
6. Waratah
7. Australian Nuclear Science and Technology Organisation
Abstract
Platinum(iv) complexes with facile modulation of lipophilicity exhibited nanomolar activity against tested lines. The most potent complexes exhibited 850-fold greater activity than cisplatin against HT29 colon carcinoma with GI50 values of 13 nM.
Funder
University of Western Sydney
Publisher
Royal Society of Chemistry (RSC)
Subject
Inorganic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/DT/C9DT03339D
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