Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes-Reference-Cited by-同舟云学术

Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes

Published:2019 Issue:42 Volume:48 Page:15856-15868
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Baecker Daniel¹²³⁴⁵,Obermoser Victoria¹²³⁴⁵,Kirchner Elisabeth Anna¹²³⁴⁵,Hupfauf Andrea¹²³⁴⁵,Kircher Brigitte⁶⁷⁸⁹¹⁰^ORCID,Gust Ronald¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry

2. Institute of Pharmacy

3. CMBI – Center for Molecular Biosciences Innsbruck

4. University of Innsbruck

5. CCB – Center for Chemistry and Biomedicine

6. Immunobiology and Stem Cell Laboratory

7. Department of Internal Medicine V (Hematology and Oncology)

8. Innsbruck Medical University

9. 6020 Innsbruck

10. Austria

Abstract

Fluorination of the lead Co-ASS yielded antitumor active cobalt alkyne complexes that exhibited both improved COX-2 selectivity and better bioanalytical sensitivity.

Funder

Landes Tirols

Österreichische Forschungsförderungsgesellschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/DT/C9DT03330K

Reference59 articles.

1. Cobalt Complexes as Antiviral and Antibacterial Agents

2. Cobalt(II) complexes with thiosemicarbazone as potential antitumor agents: synthesis, crystal structures, DNA interactions, and cytotoxicity

3. Antivitamins B 12 —A Structure‐ and Reactivity‐Based Concept

4. Cobalt derivatives as promising therapeutic agents

5. Harnessing the properties of cobalt coordination complexes for biological application

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