Mechanical and structural comparison between primary tumor and lymph node metastasis cells in colorectal cancer

Author:

Palmieri V.123,Lucchetti D.423,Maiorana A.123,Papi M.123,Maulucci G.123,Calapà F.423,Ciasca G.123,Giordano R.123,Sgambato A.423,De Spirito M.123

Affiliation:

1. Institute of Physics

2. Università Cattolica del Sacro Cuore

3. Rome, Italy

4. Institute of Pathology

Abstract

Regulation of cell mechanics allows cancer cells to acquire specialized functions. Primary tumor soft rounded cells are responsible for tumor volume increase, while elongated stiff cells invade neighbouring tissues. Once reached the lymph node, cells reorganize actin and increase adhesion to cope with high shear forces.

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

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