A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides-Reference-Cited by-同舟云学术

A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides

Published:2015 Issue:46 Volume:13 Page:11208-11219
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Miller Gavin J.¹²³⁴^ORCID,Broberg Karl. R.¹²³⁴,Rudd Claire¹²³⁴,Helliwell Madeleine R.⁵⁶⁷⁴,Jayson Gordon C.⁸⁶⁷⁴,Gardiner John M.¹²³⁴

Affiliation:

1. Manchester Institute of Biotechnology and School of Chemistry

2. 131 Princess Street

3. University of Manchester M1 7DN

4. UK

5. School of Chemistry

6. University of Manchester

7. Manchester

8. Institute or Cancer Studies and Christie Hospital

Abstract

Disaccharide units containing a latent aldehyde surrogate at O4 provide late-stage access to terminal aldehyde LMWH and HS deca and dodecasaccharides.

Funder

Medical Research Council

Cancer Research UK

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01706H

Reference39 articles.

1. Roles of heparan-sulphate glycosaminoglycans in cancer

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3. Heparan sulphate proteoglycans fine-tune mammalian physiology

4. Synthesis and medical applications of oligosaccharides

5. A synthetic CD4–heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry

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