Bioorthogonal phase-directed copper-catalyzed azide–alkyne cycloaddition (PDCuAAC) coupling of selectively cross-linked superoxide dismutase dimers produces a fully active bis-dimer-Reference-Cited by-同舟云学术

Bioorthogonal phase-directed copper-catalyzed azide–alkyne cycloaddition (PDCuAAC) coupling of selectively cross-linked superoxide dismutase dimers produces a fully active bis-dimer

Published:2015 Issue:40 Volume:13 Page:10244-10249
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Siren Erika M. J.¹²³⁴⁵,Singh Serena¹²³⁴⁵,Kluger Ronald¹²³⁴⁵

Affiliation:

1. Davenport Laboratories

2. Department of Chemistry

3. University of Toronto

4. Toronto

5. Canada M5S 3H6

Abstract

Superoxide dismutase (SOD) is a 32 kDa dimeric enzyme that actively removes a toxic oxygen species within red cells.

Funder

Canadian Blood Services

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01702E

Reference25 articles.

1. Superoxide dismutase and catalase as therapeutic agents for human diseases a critical review

2. Therapeutic potential of superoxide dismutase (SOD) for resolution of inflammation

3. Polyhemoglobin-superoxide dismutase-catalase as a blood substitute with antioxidant properties

4. Plasma elimination kinetics and renal handling of copper/zinc superoxide dismutase in the rat

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