Design and synthesis of 1,2,3-triazole–etodolac hybrids as potent anticancer molecules

Author:

Kummari Bhaskar12345ORCID,Polkam Naveen12345,Ramesh Perla6785ORCID,Anantaraju Hasithashilpa91011125,Yogeeswari Perumal91011125,Anireddy Jaya Shree12345,Guggilapu Sravanthi Devi1314155,Babu Bathini Nagendra1314155

Affiliation:

1. Centre for Chemical Sciences and Technology

2. Institute of Science and Technology

3. Jawaharlal Nehru Technological University Hyderabad

4. Hyderabad-500085

5. India

6. Natural Products Chemistry Division

7. Indian Institute of Chemical Technology

8. Hyderabad-500007

9. Department of Pharmacy

10. Birla Institute of Technology and Science

11. Pilani

12. Hyderabad Campus

13. Department of Medicinal Chemistry

14. National Institute of Pharmaceutical Education Research (NIPER)

15. Hyderabad

Abstract

A series of novel 1,2,3-triazole–etodolac hybrids (6a–l) were synthesized as potent anti-cancer molecules and the synthesis strongly relies on Huisgen's 1,3-dipolar cycloaddition between etodolac azide 3 and substituted terminal alkynes 5a–l.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference38 articles.

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