Tumor regression and potentiation of polymeric vascular disrupting therapy through reprogramming of a hypoxia microenvironment with temsirolimus-Reference-Cited by-同舟云学术

Tumor regression and potentiation of polymeric vascular disrupting therapy through reprogramming of a hypoxia microenvironment with temsirolimus

Published:2020 Issue:1 Volume:8 Page:325-332
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Yu Haiyang¹²³⁴⁵,Shen Na⁵⁶⁷⁸⁴,Bao Yanli¹²³⁴,Chen Li¹²³⁴^ORCID,Tang Zhaohui⁵⁶⁷⁸⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Northeast Normal University

3. Changchun 130024

4. People's Republic of China

5. Key Laboratory of Polymer Ecomaterials

6. Changchun Institute of Applied Chemistry

7. Chinese Academy of Sciences

8. Changchun 130022

Abstract

To relieve a tumor hypoxia microenvironment, the mTOR inhibitor temsirolimus was employed to modulate the tumor microenvironment when treated with CA4-NPs.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/BM/C9BM01398A

Reference34 articles.

1. HIF Transcription Factors, Inflammation, and Immunity

2. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer

3. The role of hypoxia-inducible factors in tumorigenesis

4. Hypoxia-inducible factor 1α is closely linked to an aggressive phenotype in breast cancer

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