Grafting synthetic transmembrane units to the engineered low-toxicity α-hemolysin to restore its hemolytic activity-Reference-Cited by-同舟云学术

Grafting synthetic transmembrane units to the engineered low-toxicity α-hemolysin to restore its hemolytic activity

Published:2014 Issue:12 Volume:10 Page:3199-3206
ISSN:1742-206X
Container-title:Mol. BioSyst.
language:en
Short-container-title:Mol. BioSyst.

Author:

Ui Mihoko¹²³,Harima Kousuke¹²³,Takei Toshiaki⁴⁵⁶⁷,Tsumoto Kouhei⁴⁵⁶⁷⁸,Tabata Kazuhito V.⁹¹⁰⁶¹¹,Noji Hiroyuki⁹¹⁰⁶¹¹,Endo Sumire¹²³,Akiyama Kimio¹²³,Muraoka Takahiro¹²³,Kinbara Kazushi¹²³

Affiliation:

1. Institute of Multidisciplinary Research for Advanced Materials

2. Tohoku University

3. Sendai 980-8577, Japan

4. Department of Medical Genome Sciences

5. Graduate School of Engineering

6. The University of Tokyo

7. Kashiwa 277-8562, Japan

8. Institute of Medical Science

9. Department of Applied Chemistry

10. School of Engineering

11. Tokyo 113-8656, Japan

Abstract

We demonstrated that staphylococcal α-hemolysin restored the hemolytic activity with chemically-synthesized prosthetic stem domains.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MB/C4MB00405A

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