Novel organo-osmium(ii) proteosynthesis inhibitors active against human ovarian cancer cells reduce gonad tumor growth inCaenorhabditis elegans-Reference-Cited by-同舟云学术

Novel organo-osmium(ii) proteosynthesis inhibitors active against human ovarian cancer cells reduce gonad tumor growth inCaenorhabditis elegans

Published:2021 Issue:1 Volume:8 Page:141-155
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Ortega Enrique¹²³⁴⁵^ORCID,Ballester Francisco J.¹²³⁴⁵^ORCID,Hernández-García Alba¹²³⁴⁵^ORCID,Hernández-García Samanta⁶⁷⁸²⁴^ORCID,Guerrero-Rubio M. Alejandra⁶⁷⁸²⁴,Bautista Delia⁹²⁴⁵,Santana M. Dolores¹²³⁴⁵^ORCID,Gandía-Herrero Fernando⁶⁷⁸²⁴,Ruiz José¹²³⁴⁵^ORCID

Affiliation:

1. Departamento de Química Inorgánica

2. Universidad de Murcia

3. and Institute for Bio-Health Research of Murcia (IMIB-Arrixaca)

4. E-30071 Murcia

5. Spain

6. Departamento de Bioquímica y Biología Molecular A

7. Unidad Docente de Biología

8. Facultad de Veterinaria

9. SAI

Abstract

Novel Os(ii) arene complexes with a deprotonated ppy or ppy-CHO C^N ligand have been synthesized to selectively act on cancer cells as proteosynthesis inhibitorsin vitroand exert antitumor activityin vivoinC. elegansmodels.

Funder

Ministerio de Ciencia e Innovación

European Regional Development Fund

Fundación Séneca

Fundación Científica Asociación Española Contra el Cáncer

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QI/C9QI01704F

Reference60 articles.