{Ru(CO)x}-Core complexes with benzimidazole ligands: synthesis, X-ray structure and evaluation of anticancer activity in vivo-Reference-Cited by-同舟云学术

{Ru(CO)x}-Core complexes with benzimidazole ligands: synthesis, X-ray structure and evaluation of anticancer activity in vivo

Published:2017 Issue:9 Volume:46 Page:3025-3040
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Tamasi Gabriella¹²³⁴⁵,Merlino Antonello⁶⁷⁸⁵⁹^ORCID,Scaletti Federica¹⁰¹¹¹²⁵,Heffeter Petra¹³¹⁴¹⁵¹⁶¹⁷,Legin Anton A.¹⁸¹⁹¹⁶¹⁷,Jakupec Michael A.²⁰¹⁹¹⁶¹⁷¹⁸^ORCID,Berger Walter¹³¹⁴¹⁵¹⁶¹⁷,Messori Luigi¹⁰¹¹¹²⁵,Keppler Bernhard K.²⁰¹⁹¹⁶¹⁷¹⁸,Cini Renzo¹²³⁴⁵

Affiliation:

1. Department of Biotechnology

2. Chemistry and Pharmacy

3. University of Siena

4. 53100 Siena

5. Italy

6. Department of Chemical Sciences

7. University of Naples Federico II

8. 80126, Napoli

9. Institute of Biostructure and Bioimaging

10. Department of Chemistry

11. University of Florence

12. 50019 Sesto Fiorentino

13. Institute of Cancer Research

14. Department of Medicine I

15. Medical University of Vienna

16. 1090 Vienna

17. Austria

18. Institute of Inorganic Chemistry

19. University of Vienna

20. Research Platform “Translational Cancer Therapy Research”

Abstract

fac-[Ru^II(CO)₃Cl₂(MBI)] and -[Ru^II(CO)₃Cl₂(DMBI)] are CO-releasing materials able to link histidines of proteins, and the latter showed antitumor effects in murine colon cancer.

Funder

European Cooperation in Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/DT/C6DT04295C

Reference67 articles.

1. Carbon Monoxide-Releasing Molecules

2. CORM-3 Reactivity toward Proteins: The Crystal Structure of a Ru(II) Dicarbonyl−Lysozyme Complex

3. {Ru(CO)x}-core complexes with selected azoles: Synthesis, X-ray structure, spectroscopy, DFT analysis and evaluation of cytotoxic activity against human cancer cells