Cleaning the molecular machinery of cells via proteostasis, proteolysis and endocytosis selectively, effectively, and precisely: intracellular self-defense and cellular perturbations

Abstract

Schematic of the regulation of the ubiquitin-protein ligases and ubiquitylation, a dynamic cellular process for stability, and induced protein folding; the ubiquitin-conjugation machinery for accurate surveillance, cell cycle arrest, DNA damage and repair, senescence, and apoptosis.