HMGB1 bound to cisplatin–DNA adducts undergoes extensive acetylation and phosphorylation in vivo-Reference-Cited by-同舟云学术

HMGB1 bound to cisplatin–DNA adducts undergoes extensive acetylation and phosphorylation in vivo

Published:2015 Issue:3 Volume:6 Page:2074-2078
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

He Yafeng¹²³⁴⁵,Ding Yin¹²³⁴⁵,Wang Dan¹²³⁴⁵,Zhang Wanjun⁶⁷⁸⁹¹⁰,Chen Weizhong¹²³⁴⁵,Liu Xichun¹²³⁴⁵,Qin Weijie⁶⁷⁸⁹¹⁰,Qian Xiaohong⁶⁷⁸⁹¹⁰,Chen Hao¹²³⁴⁵,Guo Zijian¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Coordination Chemistry

2. State Key Laboratory of Analytical Chemistry for Life Science

3. School of Chemistry and Chemical Engineering

4. Nanjing University

5. Nanjing

6. National Center for Protein Sciences Beijing

7. State Key Laboratory of Proteomics

8. Beijing Proteome Research Center

9. Institute of Radiation Medicine

10. Beijing

Abstract

Here, an application of a biomolecular probe based on a peptide–oligonucleotide conjugate is presented as a novel method for investigating the recognition of cisplatin–DNA lesions by HMGB1 in vivo.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/SC/C4SC03650F

Reference40 articles.

1. Structure, Recognition, and Processing of Cisplatin−DNA Adducts

2. Direct Cellular Responses to Platinum-Induced DNA Damage

3. The resurgence of platinum-based cancer chemotherapy

4. Molecular mechanisms of cisplatin resistance

5. Subcellular targets of cisplatin cytotoxicity: An integrated view

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