Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein-Reference-Cited by-同舟云学术

Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein

Published:2019 Issue:8 Volume:10 Page:2489-2500
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Lama Dilraj¹²³^ORCID,Liberatore Anne-Marie⁴⁵⁶,Frosi Yuri⁷²⁸,Nakhle Jessica⁴⁵⁶,Tsomaia Natia⁹¹⁰¹¹,Bashir Tarig⁴⁵⁶,Lane David P.⁷²⁸,Brown Christopher J.⁷²⁸,Verma Chandra S.¹²³¹²¹³^ORCID,Auvin Serge⁴⁵⁶

Affiliation:

1. Bioinformatics Institute

2. A*STAR (Agency for Science, Technology and Research)

3. Singapore 138671

4. Ipsen Innovation

5. Les Ulis

6. France 91940

7. p53 Laboratory

8. Singapore 138648

9. Ipsen Bioscience

10. Cambridge

11. USA

12. Department of Biological Sciences

13. National University of Singapore

Abstract

We have revealed a non-canonical recognition feature that can modulate the binding kinetics of hydrocarbon stapled-peptides interactions with the eIF4E protein.

Funder

Agency for Science, Technology and Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC03759K

Reference45 articles.

1. eIF4E: New Family Members, New Binding Partners, New Roles

2. Cap-Dependent Translation Initiation Factor eIF4E: An Emerging Anticancer Drug Target

3. Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development